Germline Stem Cells Exhibit Two Long Delays during Cytokinesis (VIDEO)
Caption
A germline stem cell (GSC, white dot), located in the testis niche (asterisk) divides to produce an attached daughter cell (yellow dot). These two cells remain connected during 'Phase One' by an F-actin ring that blocks cytokinesis. The attached cells then transition to 'Phase Two' with loss of the F-actin ring and progress of these cells toward abscission, or the physical separation of the daughter cells. Phase Two terminates with completion of abscission which is visible as a break in the connecting bridge between the daughter cells, usually occurring nearest to the stem cell daughter.
Credit
Stephen DiNardo, PhD, and Kari F. Lenhart, PhD, Perelman School of Medicine at the University of Pennsylvania; Developmental Cell
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