Predictive Power (IMAGE)

Harvard Medical School

Predictive Power

Caption

Studying related proteins, researchers identified pairs of amino acid residues (left) that seemed to change in lockstep in the evolutionary record. These co-varying pairs indicated points on protein (middle) likely to be in contact after folding, giving researchers enough clues to create a computational model of the protein's three-dimensional structure (right).

Credit

Terry Helms/Memorial Sloan-Kettering Cancer Center

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