eIF4G Microexon Exclusion Hampers Pausing of Protein Synthesis in Neurons (IMAGE)

University of Toronto

eIF4G Microexon Exclusion Hampers Pausing of Protein Synthesis in Neurons

Caption

Depicted are hippocampal neurons from a normal mouse (above) and a mouse bred to lack the eIF4G microexon (below). In the latter, there are fewer particles representing paused protein synthesis machineries. In these mice, higher levels of protein synthesis in neurons lead to disrupted brain waves and autistic behaviors as well as cognitive deficits down the line.

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Thomas Gonatopoulos-Pournatzis

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