3-Color Single-Molecule FRET Setup (IMAGE)

Technical University of Munich (TUM)

3-Color Single-Molecule FRET Setup

Caption

With their specially designed three-color single-molecule FRET (Foerster resonance energy transfer) assay with alternating laser excitation (ALEX) for simultaneous observation of ATP binding and conformational changes professor Hugel and his team could prov, that Hsp90 utilizes thermal fluctuations for its large conformational changes.

Credit

Christoph Ratzke

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