Schematic Depicting the Molecular Clutch that Is in Action during T Cell Activation (IMAGE)

University of Warwick

Schematic Depicting the Molecular Clutch that Is in Action during T Cell Activation

Caption

Schematic depicting the molecular clutch that is in action during T cell activation. The composition of LAT clusters changes on its travel towards the center leading to changes in their binding to the actin network: in the distal supramolecular activation cluster (D-SMAC) zone, LAT clusters contain Nck and WASP and bind strongly to actin network leading to their transport together with the actin retrograde flow; at the transition to the peripheral SMAC, characterized by concentric organized acto-myosin arcs, LAT clusters loose Nck and WASP leading to a weaker interaction with actin allowing them to be swept towards the central SMAC by the radially constricting acto-myosin arcs.

Credit

Dr. Darius Köster, University of Warwick

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