Genetic Variation Among CRISPR-Cas9 Target Regions (IMAGE)

Boston Children's Hospital

Genetic Variation Among CRISPR-Cas9 Target Regions

Caption

The top of this diagram shows a 30-base-pair region of a single genetic locus (HLA-A) that is involved in the immune response and could potentially be targeted with gene editing. The six smaller bars below it represent different guide RNAs that are designed to bind to different parts of that HLA-A locus. On the Y (vertical) axis are haplotypes with highlighted DNA variations identified from different individuals. They are aligned according to their positions in the genetic sequence (represented horizontally on the X axis).

Credit

Lessard S; et al. <i>PNAS Early Edition</i>, week of Dec. 11, 2017.

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