Nanoparticle Aggregation in Biological Systems (IMAGE)

World Scientific

Nanoparticle Aggregation in Biological Systems

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Nanoparticle aggregation in biological systems can occur due to interactions with ions (phosphate buffered saline, PBS), proteins (fetal bovine serum, FBS), extracellular matrix, and cells. Aggregation of iron oxide nanoparticles leads to significant reductions in heating potential and MR imaging contrast, but here we also demonstrate an empirical correlation between the two, providing new ability for image guidance of iron oxide nanoparticle heating in the clinic.

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