D2 Model (IMAGE)

University of Chicago Medical Center

D2 Model

Caption

In as many as 20 percent of people who rely on levothyroxine, a tiny genetic flaw in D2 causes the shuttling process to go astray. Those patients have a single-nucleotide substitution. As a result, one amino acid, threonine, is replaced by a different amino acid, alanine.

Credit

Antonio Bianco, MD, PhD,

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