Emerging Cancer Drugs May Drive Bone Tumors (IMAGE)

WashU Medicine

Emerging Cancer Drugs May Drive Bone Tumors

Caption

Investigational cancer drugs, IAP antagonists, may increase the risk of tumors spreading to bone. Tumors often cause bone loss, but IAP antagonist treatment accelerates the problem. The images show a bone with a tumor from a mouse treated with IAP antagonist BV6. The bone destruction is substantial, with gaping holes (left) and near total loss of the interior spongy bone (right).

Credit

Chang Yang, M.D., Ph.D.

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