IMAGE (IMAGE) National Institutes of Natural Sciences Caption This is a schematic of paCaMKII. LOV2-Jα domain derived from plant protein, phototropin 1, was fused to calcium/calmodulin-dependent protein kinase II (CaMKII). Blue light absorption causes a reversible conformational change of LOV2 domain, leading to dissociation of the kinase domain. This structurally released kinase activates downstream signaling molecules that are required for the induction of synaptic plasticity. Credit Hideji Murakoshi Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.