Chromatin Looping (IMAGE) Children's Hospital of Philadelphia Caption When enhancer and promoter elements in DNA come into contact during gene transcription, the intervening DNA sequences bend into loops made of chromatin fiber. The loop may span distances up to 100 kilobases of DNA. Credit The Children's Hospital of Philadelphia Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.