Closed Loop Controller System (IMAGE)

Brigham and Women's Hospital

Closed Loop Controller System

Caption

This is a representation of the drug delivery system. Serving as the acoustic indicator of drug delivery dosage, the microbubble emission signal y(t) is used to find the expected controller output u(f) which is fed back to help control ultrasound transducer transmission.

Credit

Tao Sun, Brigham and Women's Hospital

Usage Restrictions

Reporters may freely use this image in their coverage of this paper with credit to Tao Sun and citation of the full journal reference (Sun T et al. 'Closed-loop control of targeted ultrasound drug delivery across the blood-brain/tumor barriers in a rat glioma model' <i>Proceedings of the National Academy of Sciences</i>) doi:10.1073/pnas.1713328114

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