Gene-Drive Versus Allelic Drive (IMAGE)

University of California - San Diego

Gene-Drive Versus Allelic Drive

Caption

Gene-drive is mediated by a guide RNA (gRNA) that cuts at the exact site (scissors) where the gene-drive element (blue box: Cas9 gene; yellow box: gRNA) is inserted into the genome, resulting in full gene-drive element copying. Right panel: The new Allelic-drive is accomplished by the addition of a second gRNA (blue box) to a gene drive element that preferentially cuts a detrimental allele (scissors), but not the beneficial allele, resulting in beneficial allele copying.

Credit

Bier Lab, UC San Diego

Usage Restrictions

Must be used in conjunction with allelic drive paper.

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