Figures (IMAGE) Osaka University Caption Figure GA. Schematic summary of this study Figure 2A. Peptides of 3 to 5 small amino-acid residues which we named as γ-byproducts. Figure 3D. Semagacestat did not decrease, but rather increased the levels of γ-byproducts Figure 3E. The increasing effect of γ-byproducts by semagacestat is cancelled by knockdown of presenilin genes. Figure 3A. Semagacestat did in fact decrease secreted Aβ, as has been previously reported. Figure 3B and 3C. An accumulation of Aβ was found inside cells. Credit ©2017 Tagami et al. <i>Cell Reports</i> 21, Issue1, 259-273. doi: 10.1016/j.celrep.2017.09.032 Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.