Neuroinflammation and Psychological Disorders (IMAGE)

Florida Atlantic University

Neuroinflammation and Psychological Disorders

Caption

The image shows a reporter protein, tdTomato, in a coronal section of the brain containing hippocampus. Researchers engineered the tdTomato in the IL-1R gene so the expression of IL-1R can be visualized. In addition to expression in endothelial cells, which forms vasculature, the image shows IL-1R in the dentate gyrus (resembling teeth, hence dentate), on both side of the brain. The dentate IL-1Rs are on neurons, allowing the inflammatory cytokine IL-1 to directly signal these neurons.

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Florida Atlantic University

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