Innate Immune Adaptor TRIF Confers Neuroprotection in ALS (IMAGE)

Nagoya University

Innate Immune Adaptor TRIF Confers Neuroprotection in ALS

Caption

Abnormally activated astrocytes were accumulated in the lesion of ALS mouse without TRIF signaling, leading to accelerate motor neuron death. TRIF confers neuroprotection by eliminating abnormal astrocytes to maintain microenvironment surrounding motor neurons.

Credit

Koji Yamanaka

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