Fig.1 (IMAGE) Osaka University Caption 1) Fasting or obesity induces SDF-1 expression in adipocytes. 2) Its autocrine action activates ERK signaling. 3) SDF-1-induced ERK signal concomitantly induces serine phosphorylation of IRS-1 protein, and degrades IRS-1 protein. This attenuates 4) insulin-mediated Akt phosphorylation and 5) glucose uptake. Credit Osaka University Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.