HER2-HER3 Inactive and Active Pairs (IMAGE)

The Francis Crick Institute

HER2-HER3 Inactive and Active Pairs

Caption

Researchers found in the lab that lapatinib causes HER2 and HER3 to form pairs on cell membranes, priming them in an inactive state (left) so that when growth factors are present, they easily switch to an active pair (right) that signals to the cell to divide. Too much signalling causes cancer cells to grow aggressively.

Credit

Phospho Biomedical Animation

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