Evolving a Virus for Gene Therapy (IMAGE)
Caption
To evolve the virus best suited for gene therapy, more than 100 million engineered adeno-associated viruses (left) are injected into the gel-like center of the eye. Those able to penetrate the many cell layers of the retina are used to shuttle a corrective gene into cells with a defective gene, in particular the light-sensitive photoreceptors and the retinal pigment epithelium cells. To reach these cells, the virus must pass through the retinal ganglion cells and the inner nuclear layer (right).
Credit
David Schaffer lab, UC Berkeley
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