Scientists Report New Approach to Reduce or Prevent Renal Fibrosis (IMAGE)

Elsevier

Scientists Report New Approach to Reduce or Prevent Renal Fibrosis

Caption

Pro-inflammatory Type 1 T helper cells (Th1) immune responses mediate renal fibrogenesis. A-D: Representative Sirius Red / Fast Green-stained sections of obstructed kidneys from obstructed wild-type (WT) and T-bet-/- (T-bet KO) mice. E: Summary data for collagen deposition in WT and T-bet KO mice. F: mRNA expressions of collagen 1 (COL-1), interferon γ (IFN-γ) and interleukin 1β (IL-1β) in kidneys from obstructed WT and T-bet KO mice. *P ? 0.05 vs obstructed WT, **P ? 0.01 vs obstructed WT. Scale bars: 100μm (A-B); 50 μm (C-D).

Credit

American Journal of Pathology

Usage Restrictions

None

License

Licensed content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.