Chiral catalysts for enantioselective synthesis of Pictet-Spengler products with acyclic α-ketoesters as carbonyl source (IMAGE)

Nagoya Institute of Technology

Chiral catalysts for enantioselective synthesis of Pictet-Spengler products with acyclic α-ketoesters as carbonyl source

Caption

A sterically less-hindered (R)-isomer from the ketimine intermediate produced during the Pictet–Spengler reaction leads to pronounced enantioselectivity of the final product, which could help design advanced pharmaceutical and fertilizer products.

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Image courtesy: Shuichi Nakamura from NITech

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