New Evidence Shows Cytotoxic T Cells Can Identify, Invade, and Destroy Targets of Large Cysts (IMAGE)

Elsevier

New Evidence Shows Cytotoxic T Cells Can Identify, Invade, and Destroy Targets of Large Cysts

Caption

Three-dimensional images of T. gondii cysts containing CD8+ T cells that had fully invaded into the cysts detected in the brains of infected nude mice that received a transfer of CD8+ immune T cells. Sections (4 um thick) of their brains were applied for immunohistochemical staining for T. gondii (brown) and CD3, the T cell marker, (red), and Z-stack images were obtained using light microscopy. Upper panels show the images taken at the top and bottom of the histological section. The presence of the T cells (arrows) can be seen in both images at the top and bottom of the section. The lower panel shows a 3-dimensional image generated from the Z-stack images of the cyst at the cut-line indicated by a green arrow and line. These Z-stack images demonstrate the presence of the T cells (arrows) all the way through the sections. Scale = 10 um.

Credit

<em>The American Journal of Pathology</em>

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