Accumulation of dihydroceramides after ABC294640 administration (IMAGE)

Medical University of South Carolina

Accumulation of dihydroceramides after ABC294640 administration

Caption

The signal for ABC294640 is detected only when the drug but not the vehicle was administered (upper panel). The intensity for two different dihydroceramides is shown in the middle panel (dhC16-cer) and lower panel (dhC18-cer). A color bar indicates the signal intensity

Credit

Adapted with permission from the American Association for Cancer Research : Venant H, <i>et al</i>. The Sphingosine kinase 2 inhibitor ABC294640 reduces the growth of prostate cancer cells and results in accumulation of dihydroceramides In vitro and In vivo. <i>Molecular Cancer Therapeutics</i>; 2015 Dec; 14(12):2744-52. doi: 10.1158/1535-7163.MCT-15-0279

Usage Restrictions

The AACR expects a permission request for each subsequent form of reuse in connection with the reuse of the figure including the adaptation or revision and use in any media forms.

License

Licensed content

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.