Transcription Activator Protein (IMAGE)

Rutgers University

Transcription Activator Protein

Caption

Left: Interactions made by a transcription activator protein (TAP; light blue) with RNA polymerase α subunit C-terminal domain (αCTD; green). The interactions involve an exposed surface of TAP (AR4; violet) and an exposed surface of αCTD (yellow), occur before or during the binding of RNA polymerase to DNA, and help RNA polymerase bind to DNA. Right: Interactions made by TAP with the RNA polymerase β subunit (black and gray) and a domain of the transcription initiation factor σ that makes sequence-specific interactions with DNA (σR4; yellow). The interactions involve exposed surfaces of TAP (AR2 and AR4; green and blue) and exposed surfaces of β and σR4 (orange and pink), occur after the binding of RNA polymerase to DNA, and help RNA polymerase and σ unwind DNA.

Credit

Yu Feng and Richard H. Ebright

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