Autophagosome formation (IMAGE) Japan Science and Technology Agency Caption Isolation membranes expand to form autophagosomes by receiving lipids from endoplasmic reticulum, which is mediated by Atg2. However, Atg2 alone cannot mediate membrane expansion because lipids will accumulate at the cytoplasmic leaflet. Credit Nobuo N. Noda & Kazuaki Matoba Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.