Early Stage of Calvarial Development (IMAGE) Tokyo Medical and Dental University Caption Proposed regulatory molecular cascades in the initial layer of the calvarium (early migrating mesenchyme: EMM) at E11.5 in the wild-type mouse (a) and the mouse in which Dlx5 is overexpressed in NCC (NCCDlx5: b). ac, activator; in, inhibitor. Credit Department of Molecular Craniofacial Embryology,TMDU Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.