Nonribosomal Peptide Synthesase (VIDEO)

Washington University in St. Louis

Caption

A multi-part enzyme called a nonribosomal peptide synthetase produces the highly reactive beta-lactone ring that is responsible for obafluorin's antimicrobial activity. Understanding how antibiotic scaffolds are constructed in nature can help scientists prospect for new classes of antibiotics through DNA sequencing and genome mining. For more information: doi.org/10.1038/s41467-019-11383-7

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Timothy Wencewicz, Washington University in St. Louis

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