Disease Tolerance in Tuberculosis (IMAGE) McGill University Health Centre Caption This is a colored X-ray of a patient's chest showing disseminated, or miliary, tuberculosis (TB) in the lungs and if left untreated, it has almost 100 percent mortality rate. The lungs contain lesions (tubercles, pink) consisting of infected dead tissue. Using mouse models of TB, Tzelepis et al, have identified the critical role of mitochondrial Cyclophilin D for regulating T cell mediated immunity in disease tolerance independent of host resistance to Mycobacterium tuberculosis. Credit DU CANE MEDICAL IMAGING LTD/SCIENCE PHOTO LIBRARY Usage Restrictions CREDIT License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.