Malformed Cerebellum (IMAGE)

University of California - San Diego

Malformed Cerebellum

Caption

Animals that lack the Zfp423 gene (right) have a malformed cerebellum (cbm), including a complete loss of the midline structure (vermis). This structure is important for postural control and coordinated movement. The protein encoded by Zfp423 regulates the expression of other genes and is required for normal levels of proliferation by neural precursor cells in the cerebellum.

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UCSD Medical Center

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