DART Nanoparticles (IMAGE) University of Maryland School of Medicine Caption An illustration of the DART nanoparticle (NP) containing the chemotherapy drug paclitaxel is shown. The NP surface is coated with polyethylene glycol (PEG) to reduce clearance from the bloodstream; after reaching the tumor, the PEG coating promotes spreading within tumor tissue. DART NPs are also coated with ITEM 4, a monoclonal antibody that targets Fn14, a cell surface receptor commonly overexpressed on cancer cells. The image on the right is a transmission electron microscope (EM) picture of purified DART NPs. Credit University of Maryland School of Medicine Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.