Neutrons Paint Atomic Portrait of Prototypical Cell Signaling Enzyme (IMAGE)

DOE/Oak Ridge National Laboratory

Neutrons Paint Atomic Portrait of Prototypical Cell Signaling Enzyme

Caption

Illustration of the intricate organization of the PKA structure, wherein different parts of the protein are connected through elaborate hydrogen bonding networks (dashed yellow lines), glued together by the hydrophobic assemblies (light blue and orange volumes) -- all working together to build the functional active site. Insert shows protonation of the transferred phosphoryl group (cyan mesh) and its many interactions with water and the active site amino acid residues.

Credit

ORNL/Jill Hemman

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