Activating a Gene That Leads to Cancer (IMAGE)

Boston Children's Hospital

Activating a Gene That Leads to Cancer

Caption

This image shows how the movement of genes, or translocation, is responsible for cancers that arise from mature B-cells, such as Burkitt’s lymphoma. Chromosome 15 (in red) contains c-myc, a known oncogene. If a part of chromosome 15 becomes connected to the IgH region of the DNA, the gene regulator IgH3’RR (green) can over-activate c-myc, leading to tumors.

Credit

Courtesy of Monica Gostissa, PhD, PCMM/IDI

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Please credit Monica Gostissa, PhD

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