Activating a Gene That Leads to Cancer (IMAGE) Boston Children's Hospital Caption This image shows how the movement of genes, or translocation, is responsible for cancers that arise from mature B-cells, such as Burkitt’s lymphoma. Chromosome 15 (in red) contains c-myc, a known oncogene. If a part of chromosome 15 becomes connected to the IgH region of the DNA, the gene regulator IgH3’RR (green) can over-activate c-myc, leading to tumors. Credit Courtesy of Monica Gostissa, PhD, PCMM/IDI Usage Restrictions Please credit Monica Gostissa, PhD License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.