Structural Basis for Recognition of Frizzled Proteins by <i>Clostridium difficile</i> Toxin B (IMAGE)

University of California - Irvine

Structural Basis for Recognition of Frizzled Proteins by <i>Clostridium difficile</i> Toxin B

Caption

Clostridium difficile (C. diff) causes severe gastrointestinal tract infections. The 3-D structure shows how a key C. diff toxin, TcdB (in orange), recognizes the human Frizzled protein (in green) as its receptor to invade cells, leading to damage in the intestinal barrier. Shown in the background is immunofluorescent staining of the healthy mouse cecum tissue (left) and the one damaged by TcdB (right).

Credit

Rongsheng Jin, University of California, Irvine

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