Estrogen Promotes Increase in Cartilaginous Markers (IMAGE)

University of Kansas

Estrogen Promotes Increase in Cartilaginous Markers

Caption

Estradiol treatment in ovariectomized mice resulted in increase in collagen type II (Col2) and charged glycosaminoglycan (proteoglycans-SafO) histological staining (A) an increase in Col2 and aggrecan gene expression in WT but not estrogen receptor alpha knock out (ERαKO) mice (B) Estradiol treatment to meniscal fibrochondrocytes isolated from female WT and ERαKO mice resulted in increased gene expression of Col2 (C). n=6, *p<0.05, ^p<0.01.

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University of Kansas

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