Artificial Metalloenzyme (IMAGE)

DOE/Lawrence Berkeley National Laboratory

Artificial Metalloenzyme

Caption

The natural enzyme CYP119 (gray ribbon) was modified both by incorporation of a metal site not found in nature (iridium porphyrin, pink) and by evolution (at sites shown in yellow). The resulting bionic enzyme not only catalyzed reactions not possible with natural enzymes (left), but did so at high speed, making this bionic enzyme the first of its class to be comparably fast to a natural counterpart.

Credit

Hanna Key/Berkeley Lab

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