Asymmetric Plasma Membrane Elongation Corrects Misaligned Spindle in Late Anaphase (IMAGE)
Caption
In roughly one-quarter of dividing human cells observed by Tomomi Kiyomitsu, a postdoctoral researcher in Whitehead Institute Member Iain Cheeseman's lab, the spindle was misaligned during mitosis, even after the paired chromosomes were pulled to opposite sides of the cell in late anaphase. As seen in this merged fluorescent image (early anaphase marked with magenta; late anaphase marked with green), such cells correct this problem by adjusting their cell membranes relative to the spindle (right), instead of shifting their spindles within the cell. Cells with proper spindle alignment in early anaphase (left) do not undergo this correction.
Credit
Image courtesy of <i>Cell</i> and Tomomi Kiyomitsu/Iain Cheeseman/Whitehead Institute.
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