Developmental YAPdeltaC Rescues Adult Symptom of SCA1 (IMAGE)

_Tokyo Medical and Dental University

Developmental YAPdeltaC Rescues Adult Symptom of SCA1

Caption

Black bars indicate durations when YAPdeltaC was expressed. Pre-onset expression of YAPdeltaC, but not post-onset YAPdeltaC, elongates lifespan of SCA1 model mice. The recovery of motor function was also found in pre-onset but not post-onset expression of YAPdeltaC. These results indicate that developmental pathology regulates post-onset progression of the disease in SCA1.

Credit

Department of Neuropathology, TMDU

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