Shc is Required for Endothelial Cell Sprouting (IMAGE)

University of North Carolina Health Care

Shc is Required for Endothelial Cell Sprouting

Caption

Control endothelial cells embedded in fibrin gel sprout and form new capillary-like tubes whereas Shc knockout endothelial cells fail to form new vessels. This experiment models angiogenesis in vivo where endothelial cells must sprout off of a parent vessel in order to make a new blood vessel during development, wound healing and tumor growth.

Credit

Tzima Lab, UNC-Chapel Hill

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