PCP proteins regulate synapse numbers (IMAGE) University of California - San Diego Caption Image shows the localization and function of PCP proteins in regulating synapse numbers. Vangl2 causes synapse disassembly and Prickle antagonizes Vangl2 and promotes synapse stability. Fzd3: Frizzled3; PK: Prickle. Credit Zou lab, UC San Diego Usage Restrictions Must be used in conjunction with Science Advances paper on PCP synapse formation/maintenance. License Original content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.