USC Research (IMAGE) University of Southern California Caption In this artist's depiction, cryo-EM structures of GABAB captured in four different conformations along its activation transition appear on a neuronal synapse (background) while the structure of the GABAB receptor in the active state with agonist (orange spheres) bound in GB1 (blue) and a PAM (magenta spheres) bound on the transmembrane interface between GB1 and GB2 (yellow) appears in close-up. Credit (Illustration by Yekaterina Kadyshevskaya/Bridge Institute at the USC Michelson Center for Convergent Bioscience.) Usage Restrictions Must use credit License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.