Heat Shock Response (IMAGE) Whitehead Institute for Biomedical Research Caption Whitehead Institute researchers have determined that the master transcriptional regulator of the heat shock response, known as heat shock factor 1 (HSF1), is controlled by an on/off feedback loop and positively fine-tuned by phosphorylation. Credit Courtesy of eLife Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.