Methylene Blue Repairs Progeria-Related Damage to Cell Nuclei (IMAGE)
Caption
Methylene blue successfully repaired progeria-related defects in the nuclei of human fibroblast cells affected by the disease. The nuclei of untreated cells (panels 1 and 2, left) still exhibit the abnormal convoluted shape characteristic of progeria. The nuclei of cells treated with methylene blue for 8 weeks (panels 3 and 4, right) returned to their normal, rounded shape. The top images were stained with antibodies that attach to the normal lamin A protein, while the bottom images were stained with antibodies that attach to defective lamin A, also known as progerin.
Credit
Kan Cao/Zheng-Mei Xiong
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