Maintaining X Inactivation in Activated B cells (IMAGE)

University of Pennsylvania

Maintaining X Inactivation in Activated B cells

Caption

Researchers found that the protein YY1 brings Xist RNA back to the inactive X chromosome to maintain X chromosome inactivation in stimulated B cells. Activated, wild type B cells from female mice tightly localize Xist RNA at their inactive X chromosomes (left), whereas Xist RNA becomes dispersed throughout the entire nucleus when YY1 is deleted (right).

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University of Pennsylvania

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