VALIS Tool (IMAGE) H. Lee Moffitt Cancer Center & Research Institute Caption To perform a spatial ecological analysis the team developed a new tool called VALIS that aligns histology slides, making it possible to construct highly multiplexed images from tissues stained via immunohistochemistry (IHC) and/or immunofluorescence. This image shows one of the 11-plex IHC used in the spatial analysis, which revealed that progressed adenomas reside in an immunosuppressive niche. Credit Moffitt Cancer Center Usage Restrictions N/A License Original content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.