Nanobodies Bound to Botulinum Neurotoxin (IMAGE)

University of California - Irvine

Nanobodies Bound to Botulinum Neurotoxin

Caption

The illustration shows six nanobodies (VHHs) bound to botulinum neurotoxin (BoNT). Lam et al. report the crystal structures and neutralizing mechanisms of six unique nanobodies against two major human pathogenic BoNT type A and B. They then develop a platform for structure-based rational design of bifunctional nanobodies with superior antitoxin potencies.

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UCI School of Medicine

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