Mimicking a Natural Defense Against Malaria (IMAGE)

University of Pennsylvania School of Medicine

Mimicking a Natural Defense Against Malaria

Caption

Transmission electron micrograph images reveal lysis of the parasite digestive vacuole (DV) upon treatment with human PF4 (top right), or the small molecules PMX207 and PMX1207 (bottom) as shown by the dispersal of hemozoin fragments throughout the cytoplasm (red arrowheads) and undigested hemoglobin-containing vesicles (yellow arrowheads). Mock-treated control (top left) shows complete integrity of the DV membrane (white arrowheads), encapsulating all hemozoin crystals. (N: parasite nucleus).

Credit

Melanie G. Millholland and Doron C. Greenbaum, Perelman School of Medicine, University of Pennsylvania

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