Fig. 1 (IMAGE) Osaka University Caption Engineered biosynthetic pathway for production of glycyrrhizin in yeast. The complete glycyrrhizin biosynthetic pathway was constructed by expressing &beta;-amyrin synthase (&beta;AS), two cytochrome P450s (CYP88D6 and CYP72A63), CSyGT, UGT73P12 and UDP-glucose dehydrogenase (UGD) in yeast. The engineered yeast utilizes endogenous metabolites (2,3-oxidosqualene and UDP-glucose) as substrates, and thus able to produce glycyrrhizin from simple sugars. Credit Osaka University Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.