Purkinje Cells Model Tuberous Sclerosis Complex (IMAGE)

Boston Children's Hospital

Purkinje Cells Model Tuberous Sclerosis Complex

Caption

This Purkinje neuron was derived from patients with tuberous sclerosis and model properties of the disease at the cellular and molecular level. Sundberg and colleagues first created induced pluripotent stem cells (iPSCs) from patients' blood cells or skin cells, then differentiated them into neural progenitor cells and finally Purkinje cells.

Credit

Courtesy Maria Sundberg, PhD, Sahin Laboratory, Boston Children's Hospital

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