New Design Principle (IMAGE) National Institutes of Natural Sciences Caption (left) The strand order swapping in de novo design of larger alpha-beta proteins has been a long-standing problem for the research team. (right) Backbone ensembles generated from folding simulations identified that backbone strain caused the strand swapping. Credit NINS/IMS Usage Restrictions None License Licensed content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.