Yellow Fever Virus Image (IMAGE)

Princeton University

Yellow Fever Virus Image

Caption

Left panel: Loss of Type I IFN signaling leads to active replication of the attenuated YFV strain (YFV-17D), which is accompanied by viral invasion of the brain and damage to brain tissues (spongiosis). Right panel: The additional loss of Type III IFN signaling in Type I IFN-deficient mice impairs the integrity of the blood-brain-barrier and alters immune cell function, which aggravates spongiosis and is ultimately lethal.

Credit

Florian Douam and Alexander Ploss

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Image Credit: Florian Douam and Alexander Ploss

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